Adverse Effects of Lead Treatment: Relationship of Histopathological changes and Protective Role of Sodium selenite on Non-Diabetic and Diabetic Rat Hearts

Hatice BAŞ, Suna KALENDER, Fatma Gökçe APAYDIN
2.381 582



The present study was designed to examine the effects of lead nitrate (LN) and whether selenium has a cardioprotective effect on diabetic and non-diabetic rats. Sodium and LN were administered orally for 28 days to streptozotocin-induced diabetic and non-diabetic rats. Animals were divided into 8 groups: control, sodium selenite, LN, LN+Sodium selenite, diabetic-control, diabetic sodium selenite, diabetic LN and diabetic LN+Sodium selenite. In our present study LN caused histopathological changes in heart of animals. In the present study we found that sodium selenite treatment did not show protective effect on DM caused damages but, although not completely shown a protective.



Lead toxicity, sodium selenite, diabetes mellitus, histopathology, hearth

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