A Fourier Transform Infrared Spectrophotometry Method Used For Oseltamivir Determination in Pharmaceutical Formulations

Y ABOUL-ENEIN, Andrei A. BUNACIU, Sultana NITA, Serban FLESCHIN, Zeynep AYDOGMUS
1.511 510

Abstract


A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of oseltamivir phosphate (OP) in pharmaceutical formulations. Conventional KBr-spectra were compared for best determination of the active substance in pharmaceutical preparations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were used in data processing.

 

Key words: FT-IR analysis, oseltamivir, chemometric methods, pharmaceutical analysis.

 


Keywords


FT-IR analysis, oseltamivir, chemometric methods, pharmaceutical analysis.

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