Comparison of Serum RSH, Immunoglobulin Levels and MPO Activity in Patients with Cystic Echinococcosis in Turkey
The aim of this study was to elucidate the effect of larval form of Echinococcus granulosus on human serum antioxidant status and MPO activity and also serum immunoglobulin levels. For this research, sera of 361 patients were received who applied to Refik Saydam Hıfzıssıhha and Etlik SSK Hospital between 2003 and 2005 are suspected of the having Cystic Echinococcosis. It was found that 201 (55.7%) out of 361 patients were seropositive for the disease. Special reagent in the positive and control measured IgG, IgA and IgM levels. Total sulfhydryl groups (RSH) levels and the myeloperoxidase (MPO) activity was investigated by spectrophotometric methods. Although IgA levels increased in seropositive patients, IgG and IgM levels were not change in seropositive patient’s serum. Although MPO activity increased, RSH levels weren’t change seropositive patient’s serum. CE may alter immunoglobulin levels and antioxidant status of both female and male patients with E.granulosus infection.
Key Words:Cystic Echinococcosis (CE), Indirect Hemaglutination (IHA), Immunoglobulin (Ig), RSH, Myeloperoxidase (MPO).